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St. John’s Wort Extract Caps (0.3% Hypericin)
300 mg, 60 vegetarian capsules
Item Catalog Number: 01396 | St John’s Wort (Hypericum perforatum extract) is a weak inhibitor of monoamine oxidase (MAO), which destroys monoamine neurotransmitters including dopamine in the brain and leads to low spirits. St. John’s Wort has also been shown to inhibit reuptake of several neurotransmitters, such as serotonin, dopamine, noradrenaline, and GABA in the brain, and to reduce expression of interleukin-6.1 Each of these actions can contribute to alleviating low mood status by slowing the recycling of neurotransmitters needed for maintaining emotional balance. Flavonoids, hypericin and pseudo-hypericin, are the constituents thought to be associated with the benefits of St John’s Wort. In particular, hypericin appears to be the main active ingredient.2-7 | References
1. CNS Drugs. 2003;17:539-562.
2. Schweiz Rundsch Med Prax. 2000 Dec 14;89(50):2111-21.
3. Int J Clin Pharmacol Ther. 1999 Mar;37(3):111-9. Review.
4. Pharmacopsychiatry. 1997 Sep;30 Suppl 2:108-12.
5. Arch Intern Med. 2000 Jan 24;160(2):152-6. Review.
6. Eur Arch Psychiatry Clin Neurosci. 2003 Jun;253(3):140-8.
7. Br J Clin Pharmacol. 2002 Sep;54(3):277-82. |
| Supplement Facts | Serving Size 1 vegetarian capsule | Servings Per Container 60 | | Amount Per Serving | St. John's Wort (Hypericum perforatum) Extract (whole herb) [std. to 0.3% (0.9 mg) hypericin] | 300 mg | Other ingredients: rice flour, vegetable cellulose (capsule), vegetable stearate. | Contains rice. |
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| Dosage and Use |  | Take one capsule once or twice daily on an empty stomach, or as recommended by a healthcare practitioner. |
| | Caution | Because St. John’s Wort may have numerous drug interactions (most commonly, MAOIs and SSRIs) consult your healthcare provider before taking this product if you are taking prescription medications. Avoid prolonged exposure to UV radiation (e.g. sunlight, tanning) when using this product. | | Warnings |  |
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